The University of Oxford
room Oxford OX1 2JD
arrow_back See all Activities

Development of Triple Artemisinin-based Combination Therapies

IATI Identifier: GB-UKPRN-10007774-DeTACT

Published on IATI
  • date_range Jul 16, 2018 - Mar 31, 2024
  • autorenew Implementation (Status)

The goal of the Development of Triple Artemisinin-based Combination Therapies (DeTACT) project is to provide a solution using currently available antimalarials to contain multidrug-resistant Plasmodium falciparum malaria in the Greater Mekong Sub region, and to prevent the spread or emergence of resistance in India, Africa, and beyond. DeTACT aims to provide evidence from clinical, market and community-based research in support of a global change in policy to allow large-scale deployment of triple artemisinin-based combination therapies (TACTs) for the treatment of uncomplicated Plasmodium falciparum malaria. Switching from artemisinin-based combination therapies (ACTs) to TACTs could be one of the last available options using currently available drugs to treat multidrug-resistant falciparum malaria and prevent or delay it from spreading or emerging in areas where it is not yet present. The project is divided into six work packages: (1) Develop two co-packaged TACTs for uncomplicated P. falciparum malaria. (2) Using these products, conduct randomised, controlled, non-inferiority trials in 13 sites in 8 African countries and 4 Asian countries to provide evidence of safety, tolerability, and efficacy of the TACTs. (3) Mathematical modelling to assess the potential of TACTs to delay the emergence and further spread of antimalarial drug resistance and the costs and benefits of introducing TACTs in countries with different levels of drug resistance, malaria transmission rates, and adherence to treatment guidelines. (4) Analyse the conceptual ethical aspects and conduct an empirical ethics/social science study addressing the ethical aspects of a change to TACTs in the African paediatric patient population. (5) A market positioning assessment based on interviews and focus group discussions with stakeholders ranging from end users to national and regional policy makers, to address the barriers and strategies to overcome these, and acceptability of changing to TACTs in Asia and Africa, which present different epidemiological settings. (6) Effective communication of the design of the study and evidence generated in order to engage with key stakeholders at an early stage.

more_horiz
Sectors:
  • Malaria control

Participating Organisations

MRC Unit The Gambia at London School of Hygiene & Tropical Medicine Academic, Training and Research Implementing
FHI Clinical Private Sector Implementing
Utrecht University Academic, Training and Research Implementing
University of Rwanda Academic, Training and Research Implementing
Mahidol Oxford Tropical Medicine Research Unit - Kinshasa Academic, Training and Research Implementing
Mahidol Oxford Tropical Medicine Research Unit - Bangladesh Academic, Training and Research Implementing
Mahidol Oxford Tropical Medicine Research Unit - Cambodia Academic, Training and Research Implementing
Mahidol Oxford Tropical Medicine Research Unit - Thailand Academic, Training and Research Implementing
Centre National de Formation et de Recherche en Sante Rurale (CNFRSR) de Maferinyah Academic, Training and Research Implementing
Epicentre Niger Academic, Training and Research Implementing
Centre for Malaria and Other Tropical Diseases (CEMTROD), University of Ilorin Teaching Hospital, Nigeria Academic, Training and Research Implementing
Institut des Sciences et Techniques (INSTech), Burkina Faso Academic, Training and Research Implementing
National Institute for Medical Research (NIMR), Tanzania Academic, Training and Research Implementing
National Center for Parasitology Entomology and Malaria Control (CNM), Cambodia Government Implementing
UK- Foreign Commonwealth and Development Office Government Funding
The University of Oxford Academic, Training and Research Accountable
University of Kinshasa Academic, Training and Research Implementing
Oxford University Clinical Research Unit- Indonesia Academic, Training and Research Implementing

Transaction

Transaction Value Provider
Receiver
Type Date
70,093 GBP Provider N/A MRC Unit The Gambia at London School of Hygiene & Tropical Medicine Disbursement
date_range Nov 02, 2022
9,300 GBP Provider N/A National Center for Parasitology Entomology and Malaria Control (CNM), Cambodia Disbursement
date_range Oct 03, 2022
2,908 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand Disbursement
date_range Oct 03, 2022
28,445 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Bangladesh Disbursement
date_range Oct 03, 2022
52,460 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Cambodia Disbursement
date_range Oct 03, 2022
77,665 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand Disbursement
date_range Oct 03, 2022
11,187 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Kinshasa Disbursement
date_range Oct 03, 2022
690,128 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand Disbursement
date_range Oct 03, 2022
6,637 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand Disbursement
date_range Oct 03, 2022
16,275 GBP Provider N/A Oxford University Clinical Research Unit - Indonesia Disbursement
date_range Oct 03, 2022
34,535 GBP Provider N/A MRC Unit The Gambia at London School of Hygiene & Tropical Medicine Disbursement
date_range Sep 14, 2022
462,129 GBP UK Foreign, Commonwealth and Development Office The University of Oxford Incoming Funds
date_range Sep 08, 2022
16,003 GBP Provider N/A Centre for Malaria and Other Tropical Diseases Care, University of Ilorin, Nigeria Disbursement
date_range Sep 05, 2022
2,212 GBP Provider N/A FHI-Clinical Disbursement
date_range Aug 26, 2022
92,925 GBP Provider N/A Institut des Sciences et Techniques (INSTech), Burkina Faso Disbursement
date_range Aug 26, 2022
42,639 GBP Provider N/A Centre for Malaria and Other Tropical Diseases Care, University of Ilorin, Nigeria Disbursement
date_range Aug 26, 2022
66,005 GBP Provider N/A University of Rwanda Disbursement
date_range Aug 26, 2022
94,293 GBP Provider N/A National Institute for Medical Research (NIMR), Tanzania Disbursement
date_range Aug 19, 2022
36,863 GBP Provider N/A MRC Unit The Gambia at London School of Hygiene & Tropical Medicine Disbursement
date_range Aug 17, 2022
15,559 GBP Provider N/A University of Kinshasa Disbursement
date_range May 25, 2022
571,241 GBP UK Foreign, Commonwealth and Development Office The University of Oxford Incoming Funds
date_range May 12, 2022
43,128 GBP Provider N/A Centre for Malaria and Other Tropical Diseases Care, University of Ilorin, Nigeria Disbursement
date_range Apr 12, 2022
49,848 GBP Provider N/A FHI-Clinical Disbursement
date_range Mar 14, 2022
4,650 GBP Provider N/A National Centre for Parasitology Entomology and Malaria Control (CNM), Cambodia Disbursement
date_range Mar 09, 2022
5,858 GBP Provider N/A FHI-Clinical Disbursement
date_range Mar 09, 2022
729,548 GBP UK Foreign, Commonwealth and Development Office The University of Oxford Incoming Funds
date_range Mar 09, 2022
121,435 GBP Provider N/A MRC Unit The Gambia at London School of Hygiene & Tropical Medicine Disbursement
date_range Feb 09, 2022
60,545 GBP Provider N/A Utrecht University Disbursement
date_range Feb 09, 2022
60,545 GBP Provider N/A Utrecht University Disbursement
date_range Feb 03, 2022
55,710 GBP Provider N/A Centre National de Formation et de Recherche en Sante Rurale (CNFRSR) de Maferinyah, Guinea Disbursement
date_range Jan 07, 2022
93,379 GBP Provider N/A University of Rwanda Disbursement
date_range Jan 07, 2022
70,725 GBP Provider N/A FHI-Clinical Disbursement
date_range Dec 13, 2021
52,180 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand Disbursement
date_range Dec 13, 2021
213,057 GBP Provider N/A Institut des Sciences et Techniques (INSTech), Burkina Faso Disbursement
date_range Dec 13, 2021
61,868 GBP Provider N/A National Institute for Medical Research (NIMR), Tanzania Disbursement
date_range Dec 13, 2021
24,617 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Bangladesh Disbursement
date_range Dec 13, 2021
20,145 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand Disbursement
date_range Dec 13, 2021
5,713 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand Disbursement
date_range Dec 13, 2021
39,236 GBP Provider N/A Centre for Malaria and Other Tropical Diseases Care, University of Ilorin, Nigeria Disbursement
date_range Dec 13, 2021
285,463 GBP Provider N/A Utrecht University Disbursement
date_range Dec 13, 2021
305,054 GBP Provider N/A University of Kinshasa Disbursement
date_range Dec 13, 2021
42,625 GBP Provider N/A National Centre for Parasitology Entomology and Malaria Control (CNM), Cambodia Disbursement
date_range Dec 13, 2021
35,116 GBP Provider N/A Institut des Sciences et Techniques (INSTech), Burkina Faso Disbursement
date_range Dec 13, 2021
39,629 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Cambodia Disbursement
date_range Dec 13, 2021
42,444 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Kinshasa Disbursement
date_range Dec 13, 2021
1,473,162 GBP Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand Disbursement
date_range Dec 13, 2021
637,608 GBP UK Foreign, Commonwealth and Development Office The University of Oxford Incoming Funds
date_range Nov 16, 2021
230,001 GBP UK Foreign, Commonwealth and Development Office The University of Oxford Incoming Funds
date_range Sep 23, 2021
322,861 GBP Provider N/A Epicentre Niger Disbursement
date_range Jul 27, 2021
1,450,180 GBP UK Foreign, Commonwealth and Development Office The University of Oxford Incoming Funds
date_range Mar 31, 2021
68,308 GBP Provider N/A University of Rwanda Disbursement
date_range Mar 02, 2021
1,131,667 GBP UK Foreign, Commonwealth and Development Office The University of Oxford Incoming Funds
date_range Mar 31, 2020
70,019 GBP Provider N/A The University of Oxford Disbursement
date_range Aug 25, 2019
501,553 GBP UK Foreign, Commonwealth and Development Office The University of Oxford Incoming Funds
date_range Mar 31, 2019
854,225 GBP Provider N/A The University of Oxford Disbursement
date_range Jul 29, 2018
626,371 GBP Provider N/A The University of Oxford Disbursement
date_range Jul 29, 2018

Budget

11,801,777 USD
  • 501,551 GBP (Valued at Jul 16, 2018)
    date_range Jul 16, 2018 - Mar 31, 2019
  • 1,131,668 GBP (Valued at Apr 01, 2019)
    date_range Apr 01, 2019 - Mar 31, 2020
  • 1,450,180 GBP (Valued at Apr 01, 2020)
    date_range Apr 01, 2020 - Mar 31, 2021
  • 2,928,871 GBP (Valued at Apr 01, 2021)
    date_range Apr 01, 2021 - Mar 31, 2022
  • 1,029,828 GBP (Valued at Apr 01, 2022)
    date_range Apr 01, 2022 - Mar 31, 2023
  • 2,185,068 GBP (Valued at Oct 03, 2022)
    date_range Apr 01, 2021 - Mar 31, 2022
access_time Updated on Nov 02, 2022 02:23:57