IATI Identifier: GB-UKPRN-10007774-DeTACT
The goal of the Development of Triple Artemisinin-based Combination Therapies (DeTACT) project is to provide a solution using currently available antimalarials to contain multidrug-resistant Plasmodium falciparum malaria in the Greater Mekong Sub region, and to prevent the spread or emergence of resistance in India, Africa, and beyond. DeTACT aims to provide evidence from clinical, market and community-based research in support of a global change in policy to allow large-scale deployment of triple artemisinin-based combination therapies (TACTs) for the treatment of uncomplicated Plasmodium falciparum malaria. Switching from artemisinin-based combination therapies (ACTs) to TACTs could be one of the last available options using currently available drugs to treat multidrug-resistant falciparum malaria and prevent or delay it from spreading or emerging in areas where it is not yet present. The project is divided into six work packages: (1) Develop two co-packaged TACTs for uncomplicated P. falciparum malaria. (2) Using these products, conduct randomised, controlled, non-inferiority trials in 13 sites in 8 African countries and 4 Asian countries to provide evidence of safety, tolerability, and efficacy of the TACTs. (3) Mathematical modelling to assess the potential of TACTs to delay the emergence and further spread of antimalarial drug resistance and the costs and benefits of introducing TACTs in countries with different levels of drug resistance, malaria transmission rates, and adherence to treatment guidelines. (4) Analyse the conceptual ethical aspects and conduct an empirical ethics/social science study addressing the ethical aspects of a change to TACTs in the African paediatric patient population. (5) A market positioning assessment based on interviews and focus group discussions with stakeholders ranging from end users to national and regional policy makers, to address the barriers and strategies to overcome these, and acceptability of changing to TACTs in Asia and Africa, which present different epidemiological settings. (6) Effective communication of the design of the study and evidence generated in order to engage with key stakeholders at an early stage.
more_horizMalaria control
Name | Type | Role |
---|---|---|
MRC Unit The Gambia at London School of Hygiene & Tropical Medicine | Academic, Training and Research | Implementing |
FHI Clinical | Private Sector | Implementing |
Utrecht University | Academic, Training and Research | Implementing |
University of Rwanda | Academic, Training and Research | Implementing |
Mahidol Oxford Tropical Medicine Research Unit - Kinshasa | Academic, Training and Research | Implementing |
Mahidol Oxford Tropical Medicine Research Unit - Bangladesh | Academic, Training and Research | Implementing |
Mahidol Oxford Tropical Medicine Research Unit - Cambodia | Academic, Training and Research | Implementing |
Mahidol Oxford Tropical Medicine Research Unit - Thailand | Academic, Training and Research | Implementing |
Centre National de Formation et de Recherche en Sante Rurale (CNFRSR) de Maferinyah | Academic, Training and Research | Implementing |
Epicentre Niger | Academic, Training and Research | Implementing |
Centre for Malaria and Other Tropical Diseases (CEMTROD), University of Ilorin Teaching Hospital, Nigeria | Academic, Training and Research | Implementing |
Institut des Sciences et Techniques (INSTech), Burkina Faso | Academic, Training and Research | Implementing |
National Institute for Medical Research (NIMR), Tanzania | Academic, Training and Research | Implementing |
National Center for Parasitology Entomology and Malaria Control (CNM), Cambodia | Government | Implementing |
UK- Foreign Commonwealth and Development Office | Government | Funding |
The University of Oxford | Academic, Training and Research | Accountable |
University of Kinshasa | Academic, Training and Research | Implementing |
Oxford University Clinical Research Unit- Indonesia | Academic, Training and Research | Implementing |
Transaction Value |
Provider
Receiver |
Type | Date |
---|---|---|---|
70,093 GBP (Valued at Nov 02, 2022) | Provider N/A MRC Unit The Gambia at London School of Hygiene & Tropical Medicine | Disbursement |
date_range
Nov 02, 2022
|
9,300 GBP (Valued at Oct 03, 2022) | Provider N/A National Center for Parasitology Entomology and Malaria Control (CNM), Cambodia | Disbursement |
date_range
Oct 03, 2022
|
2,908 GBP (Valued at Oct 03, 2022) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand | Disbursement |
date_range
Oct 03, 2022
|
28,445 GBP (Valued at Oct 03, 2022) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Bangladesh | Disbursement |
date_range
Oct 03, 2022
|
52,460 GBP (Valued at Oct 03, 2022) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Cambodia | Disbursement |
date_range
Oct 03, 2022
|
77,665 GBP (Valued at Oct 03, 2022) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand | Disbursement |
date_range
Oct 03, 2022
|
11,187 GBP (Valued at Oct 03, 2022) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Kinshasa | Disbursement |
date_range
Oct 03, 2022
|
690,128 GBP (Valued at Oct 03, 2022) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand | Disbursement |
date_range
Oct 03, 2022
|
6,637 GBP (Valued at Oct 03, 2022) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand | Disbursement |
date_range
Oct 03, 2022
|
16,275 GBP (Valued at Oct 03, 2022) | Provider N/A Oxford University Clinical Research Unit - Indonesia | Disbursement |
date_range
Oct 03, 2022
|
34,535 GBP (Valued at Sep 14, 2022) | Provider N/A MRC Unit The Gambia at London School of Hygiene & Tropical Medicine | Disbursement |
date_range
Sep 14, 2022
|
462,129 GBP (Valued at Sep 08, 2022) | UK Foreign, Commonwealth and Development Office The University of Oxford | Incoming Funds |
date_range
Sep 08, 2022
|
16,003 GBP (Valued at Sep 05, 2022) | Provider N/A Centre for Malaria and Other Tropical Diseases Care, University of Ilorin, Nigeria | Disbursement |
date_range
Sep 05, 2022
|
2,212 GBP (Valued at Aug 26, 2022) | Provider N/A FHI-Clinical | Disbursement |
date_range
Aug 26, 2022
|
92,925 GBP (Valued at Aug 26, 2022) | Provider N/A Institut des Sciences et Techniques (INSTech), Burkina Faso | Disbursement |
date_range
Aug 26, 2022
|
42,639 GBP (Valued at Aug 26, 2022) | Provider N/A Centre for Malaria and Other Tropical Diseases Care, University of Ilorin, Nigeria | Disbursement |
date_range
Aug 26, 2022
|
66,005 GBP (Valued at Aug 26, 2022) | Provider N/A University of Rwanda | Disbursement |
date_range
Aug 26, 2022
|
94,293 GBP (Valued at Aug 19, 2022) | Provider N/A National Institute for Medical Research (NIMR), Tanzania | Disbursement |
date_range
Aug 19, 2022
|
36,863 GBP (Valued at Aug 17, 2022) | Provider N/A MRC Unit The Gambia at London School of Hygiene & Tropical Medicine | Disbursement |
date_range
Aug 17, 2022
|
15,559 GBP (Valued at May 25, 2022) | Provider N/A University of Kinshasa | Disbursement |
date_range
May 25, 2022
|
571,241 GBP (Valued at Jun 13, 2022) | UK Foreign, Commonwealth and Development Office The University of Oxford | Incoming Funds |
date_range
May 12, 2022
|
43,128 GBP (Valued at Apr 12, 2022) | Provider N/A Centre for Malaria and Other Tropical Diseases Care, University of Ilorin, Nigeria | Disbursement |
date_range
Apr 12, 2022
|
49,848 GBP (Valued at Mar 14, 2022) | Provider N/A FHI-Clinical | Disbursement |
date_range
Mar 14, 2022
|
4,650 GBP (Valued at Mar 09, 2022) | Provider N/A National Centre for Parasitology Entomology and Malaria Control (CNM), Cambodia | Disbursement |
date_range
Mar 09, 2022
|
5,858 GBP (Valued at Mar 09, 2022) | Provider N/A FHI-Clinical | Disbursement |
date_range
Mar 09, 2022
|
729,548 GBP (Valued at Mar 09, 2022) | UK Foreign, Commonwealth and Development Office The University of Oxford | Incoming Funds |
date_range
Mar 09, 2022
|
121,435 GBP (Valued at Feb 09, 2022) | Provider N/A MRC Unit The Gambia at London School of Hygiene & Tropical Medicine | Disbursement |
date_range
Feb 09, 2022
|
60,545 GBP (Valued at Feb 09, 2022) | Provider N/A Utrecht University | Disbursement |
date_range
Feb 09, 2022
|
60,545 GBP (Valued at Feb 03, 2022) | Provider N/A Utrecht University | Disbursement |
date_range
Feb 03, 2022
|
55,710 GBP (Valued at Jan 07, 2022) | Provider N/A Centre National de Formation et de Recherche en Sante Rurale (CNFRSR) de Maferinyah, Guinea | Disbursement |
date_range
Jan 07, 2022
|
93,379 GBP (Valued at Jan 07, 2022) | Provider N/A University of Rwanda | Disbursement |
date_range
Jan 07, 2022
|
70,725 GBP (Valued at Dec 13, 2021) | Provider N/A FHI-Clinical | Disbursement |
date_range
Dec 13, 2021
|
52,180 GBP (Valued at Dec 13, 2021) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand | Disbursement |
date_range
Dec 13, 2021
|
213,057 GBP (Valued at Dec 13, 2021) | Provider N/A Institut des Sciences et Techniques (INSTech), Burkina Faso | Disbursement |
date_range
Dec 13, 2021
|
61,868 GBP (Valued at Dec 13, 2021) | Provider N/A National Institute for Medical Research (NIMR), Tanzania | Disbursement |
date_range
Dec 13, 2021
|
24,617 GBP (Valued at Dec 13, 2021) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Bangladesh | Disbursement |
date_range
Dec 13, 2021
|
20,145 GBP (Valued at Dec 13, 2021) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand | Disbursement |
date_range
Dec 13, 2021
|
5,713 GBP (Valued at Dec 13, 2021) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand | Disbursement |
date_range
Dec 13, 2021
|
39,236 GBP (Valued at Dec 13, 2021) | Provider N/A Centre for Malaria and Other Tropical Diseases Care, University of Ilorin, Nigeria | Disbursement |
date_range
Dec 13, 2021
|
285,463 GBP (Valued at Dec 13, 2021) | Provider N/A Utrecht University | Disbursement |
date_range
Dec 13, 2021
|
305,054 GBP (Valued at Dec 13, 2021) | Provider N/A University of Kinshasa | Disbursement |
date_range
Dec 13, 2021
|
42,625 GBP (Valued at Dec 13, 2021) | Provider N/A National Centre for Parasitology Entomology and Malaria Control (CNM), Cambodia | Disbursement |
date_range
Dec 13, 2021
|
35,116 GBP (Valued at Dec 13, 2021) | Provider N/A Institut des Sciences et Techniques (INSTech), Burkina Faso | Disbursement |
date_range
Dec 13, 2021
|
39,629 GBP (Valued at Dec 13, 2021) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Cambodia | Disbursement |
date_range
Dec 13, 2021
|
42,444 GBP (Valued at Dec 13, 2021) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Kinshasa | Disbursement |
date_range
Dec 13, 2021
|
1,473,162 GBP (Valued at Dec 13, 2021) | Provider N/A Mahidol Oxford Tropical Medicine Research Unit - Thailand | Disbursement |
date_range
Dec 13, 2021
|
637,608 GBP (Valued at Dec 13, 2021) | UK Foreign, Commonwealth and Development Office The University of Oxford | Incoming Funds |
date_range
Nov 16, 2021
|
230,001 GBP (Valued at Sep 23, 2021) | UK Foreign, Commonwealth and Development Office The University of Oxford | Incoming Funds |
date_range
Sep 23, 2021
|
322,861 GBP (Valued at Jul 27, 2021) | Provider N/A Epicentre Niger | Disbursement |
date_range
Jul 27, 2021
|
1,450,180 GBP (Valued at Mar 31, 2021) | UK Foreign, Commonwealth and Development Office The University of Oxford | Incoming Funds |
date_range
Mar 31, 2021
|
68,308 GBP (Valued at Mar 02, 2021) | Provider N/A University of Rwanda | Disbursement |
date_range
Mar 02, 2021
|
1,131,667 GBP (Valued at Mar 31, 2020) | UK Foreign, Commonwealth and Development Office The University of Oxford | Incoming Funds |
date_range
Mar 31, 2020
|
70,019 GBP (Valued at Aug 25, 2019) | Provider N/A The University of Oxford | Disbursement |
date_range
Aug 25, 2019
|
501,553 GBP (Valued at Mar 31, 2019) | UK Foreign, Commonwealth and Development Office The University of Oxford | Incoming Funds |
date_range
Mar 31, 2019
|
854,225 GBP (Valued at Jul 29, 2018) | Provider N/A The University of Oxford | Disbursement |
date_range
Jul 29, 2018
|
626,371 GBP (Valued at Jul 29, 2018) | Provider N/A The University of Oxford | Disbursement |
date_range
Jul 29, 2018
|