IATI Identifier: GB-COH-RC000660-War-PATH
The War-PATH NIHR Global Research Group is between the University of Liverpool and two low and middle income countries (LMICs), Uganda and South Africa. It will focus on a clinically important noncommunicable disease area which requires the use of anticoagulation. Anticoagulants, in particular warfarin, are used in these countries for the treatment of venous thromboembolism, rheumatic heart disease and prevention of strokes in patients with irregular heart rhythms (atrial fibrillation). Anticoagulation represents an unmet clinical need in Sub-Saharan Africa as patients either do not receive anticoagulation (because of difficulties in monitoring) or are poorly anticoagulated because of poor dosing guidelines. This results in potentially preventable morbidity and mortality which affects the poorer sectors of the population in particular. We have extensive expertise in the UK and EU of improving the use of warfarin through the development of novel dosing algorithms, which have now began incorporating genetic factors. By contrast, in our two collaborating partner countries, no good dosing algorithms exist, even those which only take into account clinical factors. The situation in these 2 countries is further complicated by the fact that there is a high prevalence of HIV and TB, which make anticoagulation harder because (a) they increase the risk of thrombosis, and (b) the drugs used for treatment interact with warfarin. Our research will focus on: (a) evaluating the quality of anticoagulant services in Cape Town and Kampala taking into account the indications, anticoagulant clinic set-up and quality of anticoagulation control; (b) recruiting patients currently on warfarin to identify clinical factors determining anticoagulation quality to develop a dosing algorithm; (c) a study to implement the clinical algorithm in the two sites; and (d) evaluating genes specific to the African population that can impact on anticoagulation control, and the development of novel genetic dosing algorithms. The work will be accompanied by education and training of the local workforce to improve local capability and capacity. We will also train 4 students to Masters level, and 2 post-doctoral researchers will be seconded to Liverpool to gain training in high-end genomics. We will also engage with regional health policy makers in both countries to develop the best pathways for implementing the research findings to improve anticoagulation care, for the benefit of patients, the local society and ultimately the economy. We will also work with technology companies to develop long-term cost-effective strategies to implement novel technologies that will allow for point-of-care testing of anticoagulation, and also of genetic markers.
more_horizName | Type | Role |
---|---|---|
NIHR | Government | Funding |
Makerere University | Academic, Training and Research | Implementing |
University of Cape Town | Academic, Training and Research | Implementing |
University Of Liverpool | Academic, Training and Research | Implementing |
University of Bangor | Academic, Training and Research | Implementing |
Transaction Value |
Provider
Receiver |
Type | Date |
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21,697 GBP (Valued at Jun 03, 2021) | Provider N/A Receiver N/A | Disbursement |
date_range
Jun 03, 2021
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12,233 GBP (Valued at Apr 20, 2021) | Provider N/A Receiver N/A | Disbursement |
date_range
Apr 20, 2021
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181,306 GBP (Valued at Mar 25, 2021) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Mar 25, 2021
|
15,995 GBP (Valued at Feb 04, 2021) | Provider N/A Receiver N/A | Disbursement |
date_range
Feb 04, 2021
|
14,266 GBP (Valued at Jan 21, 2021) | Provider N/A Receiver N/A | Disbursement |
date_range
Jan 21, 2021
|
218,897 GBP (Valued at Dec 01, 2020) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Dec 01, 2020
|
11,435 GBP (Valued at Oct 29, 2020) | Provider N/A Receiver N/A | Disbursement |
date_range
Oct 29, 2020
|
16,462 GBP (Valued at Oct 23, 2020) | Provider N/A Receiver N/A | Disbursement |
date_range
Oct 23, 2020
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82,321 GBP (Valued at Oct 01, 2020) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Oct 01, 2020
|
25,085 GBP (Valued at Aug 07, 2020) | Provider N/A Receiver N/A | Disbursement |
date_range
Aug 07, 2020
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14,779 GBP (Valued at Jul 27, 2020) | Provider N/A Receiver N/A | Disbursement |
date_range
Jul 27, 2020
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27,613 GBP (Valued at Jun 19, 2020) | Provider N/A Receiver N/A | Disbursement |
date_range
Jun 19, 2020
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32,839 GBP (Valued at Jun 18, 2020) | Provider N/A Receiver N/A | Disbursement |
date_range
Jun 18, 2020
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17,999 GBP (Valued at Apr 24, 2020) | Provider N/A Receiver N/A | Disbursement |
date_range
Apr 24, 2020
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142,567 GBP (Valued at Mar 31, 2020) | Provider N/A Receiver N/A | Expenditure |
date_range
Mar 31, 2020
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332,887 GBP (Valued at Mar 24, 2020) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Mar 24, 2020
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24,258 GBP (Valued at Feb 05, 2020) | Provider N/A Receiver N/A | Disbursement |
date_range
Feb 05, 2020
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113,509 GBP (Valued at Dec 31, 2019) | Provider N/A Receiver N/A | Expenditure |
date_range
Dec 31, 2019
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222,286 GBP (Valued at Dec 17, 2019) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Dec 17, 2019
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26,274 GBP (Valued at Dec 11, 2019) | Provider N/A Receiver N/A | Disbursement |
date_range
Dec 11, 2019
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24,082 GBP (Valued at Oct 19, 2019) | Provider N/A Receiver N/A | Disbursement |
date_range
Oct 19, 2019
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23,327 GBP (Valued at Oct 07, 2019) | Provider N/A Receiver N/A | Disbursement |
date_range
Oct 07, 2019
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76,295 GBP (Valued at Oct 01, 2019) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Oct 01, 2019
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110,590 GBP (Valued at Sep 30, 2019) | Provider N/A Receiver N/A | Expenditure |
date_range
Sep 30, 2019
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19,323 GBP (Valued at Jul 31, 2019) | Provider N/A Receiver N/A | Disbursement |
date_range
Jul 31, 2019
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23,329 GBP (Valued at Jul 30, 2019) | Provider N/A Receiver N/A | Disbursement |
date_range
Jul 30, 2019
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92,117 GBP (Valued at Jun 30, 2019) | Provider N/A Receiver N/A | Expenditure |
date_range
Jun 30, 2019
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83,904 GBP (Valued at Jun 27, 2019) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Jun 27, 2019
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218,080 GBP (Valued at Apr 02, 2019) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Apr 02, 2019
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92,775 GBP (Valued at Mar 31, 2019) | Provider N/A Receiver N/A | Expenditure |
date_range
Mar 31, 2019
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20,546 GBP (Valued at Mar 31, 2019) | Provider N/A Receiver N/A | Disbursement |
date_range
Mar 31, 2019
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27,492 GBP (Valued at Feb 04, 2019) | Provider N/A Receiver N/A | Disbursement |
date_range
Feb 04, 2019
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14,524 GBP (Valued at Jan 30, 2019) | Provider N/A Receiver N/A | Disbursement |
date_range
Jan 30, 2019
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130,965 GBP (Valued at Dec 31, 2018) | Provider N/A Receiver N/A | Expenditure |
date_range
Dec 31, 2018
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207,960 GBP (Valued at Dec 27, 2018) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Dec 27, 2018
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18,259 GBP (Valued at Dec 07, 2018) | Provider N/A Receiver N/A | Disbursement |
date_range
Dec 07, 2018
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17,334 GBP (Valued at Nov 13, 2018) | Provider N/A Receiver N/A | Disbursement |
date_range
Nov 13, 2018
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18,045 GBP (Valued at Oct 11, 2018) | Provider N/A Receiver N/A | Disbursement |
date_range
Oct 11, 2018
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117,672 GBP (Valued at Oct 02, 2018) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Oct 02, 2018
|
69,988 GBP (Valued at Sep 30, 2018) | Provider N/A Receiver N/A | Expenditure |
date_range
Sep 30, 2018
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14,407 GBP (Valued at Aug 08, 2018) | Provider N/A Receiver N/A | Disbursement |
date_range
Aug 08, 2018
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143,397 GBP (Valued at Jul 03, 2018) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Jul 03, 2018
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69,692 GBP (Valued at Jun 30, 2018) | Provider N/A Receiver N/A | Expenditure |
date_range
Jun 30, 2018
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2,446 GBP (Valued at Jun 12, 2018) | Provider N/A Receiver N/A | Disbursement |
date_range
Jun 12, 2018
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5,859 GBP (Valued at Jun 11, 2018) | Provider N/A Receiver N/A | Disbursement |
date_range
Jun 11, 2018
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9,048 GBP (Valued at Apr 23, 2018) | Provider N/A Receiver N/A | Disbursement |
date_range
Apr 23, 2018
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150,399 GBP (Valued at Mar 31, 2018) | Provider N/A Receiver N/A | Expenditure |
date_range
Mar 31, 2018
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96,326 GBP (Valued at Mar 27, 2018) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Mar 27, 2018
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54,850 GBP (Valued at Mar 01, 2018) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Mar 01, 2018
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50,000 GBP (Valued at Oct 12, 2017) | Provider N/A Receiver N/A | Incoming Funds |
date_range
Oct 12, 2017
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